Department of Biosciences and Bioengineering
Indian Institute of Technology Guwahati

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Department Biosciences and Bioengineering
Indian Institute of Technology Guwahati
Guwahati 781039

Telephone:
(0361) 258-2250
Fax: (0361) 258-2249
E-mail: biooff@iitg.ernet.in

 

Aiyagari Ramesh, Ph.D.
Professor

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   Aiyagari Ramesh, Ph.D.
   Professor
   Department of Biosciences and Bioengineering
   Indian Institute of Technology Guwahati
   Guwahati 781039
   Tel: +91-361-2582205
   Fax: +91-361-2249
   E-mail: aramesh@iitg.ernet.in
   Webpage: www.iitg.ernet.in/biotech/A.Ramesh.html

Academics

Qualifications

   M.Sc. (Zoology), Calcutta University, 1991

   M.Tech (Biotechnology & Engineering), Indian Institute of Technology Kharagpur, 1993

   Ph.D. (Biotechnology), Central Food Technological Research Institute (CFTRI), Mysore, 2001

Research Areas

   Nanobiotechnology, Chemistry-Biology Interface for Developing Antibacterials and Sensors 

Selected Research Publications

1.  Kapoor, V., Rai, R., Thiyagarajan, D., Mukherjee, S., Das, G. and Ramesh, A. (2017). Non-bactericidal zinc-complexing ligand as a biofilm inhibitor: structure-guided contrasting effect on Staphylococcus aureus biofilm. ChemBioChem (DOI: 10.1002/cbic.201700139).

2.  Samanta, S., Dey, P., Ramesh, A. and Das, G. (2016). A solo fluorogenic probe for real-time sensing of SO32- and SO42-/HSO4- in aqueous medium and live cells by distinct turn-on emission signals. Chemical Communications, 52, 10381-10384.

3.  Thiyagarajan, D., Das, G. and Ramesh, A. (2016). Extracellular DNA-targeting nanomaterial for effective elimination of biofilm. ChemNanoMat 2, 879 - 887.

4.  Mukherjee, S. and Ramesh, A. (2015). Bacteriocin producing strains of Lactobacillus plantarum inhibit adhesion of Staphylococcus aureus to extracellular matrix (ECM): Quantitative insight and implications in antibacterial therapy. Journal of Medical Microbiology, 64, 1514-1526.

5. Goswami, S., Thiyagarajan, D., Samanta, S., Das, G. and Ramesh, A. (2015). A zinc complex of a neutral pyridine-based amphiphile: a highly efficient and potentially therapeutic bactericidal material. Journal of Materials Chemistry B, 3, 7068-7078.

6.  Gogoi, A., Mukherjee, S., Ramesh, A. and Das, G. (2015). Nanomolar Zn(II) sensing and subsequent PPi detection in physiological medium and live cells with a benzothiazole functionalized chemosensor. RSC Advances, 5, 63634-63640.

7.  Gogoi, A., Mukherjee, S., Ramesh, A. and Das, G. (2015). Aggregation-induced emission active metal-free chemosensing platform for highly selective turn-ON sensing and bioimaging of pyrophosphate anion. Analytical Chemistry 87, 6974-6979.

8.  Datta, B. K., Thiyagarajan, D., Ramesh, A. and Das, G. (2015). A sole multi-analyte receptor responds with three distinct fluorescence signals: Traffic signal like sensing of Al3+, Zn2+ and F. Dalton Transactions 44, 13093-13099.

9.  Samanta, S., Goswami, S., Ramesh, A. and Das, G. (2015). A new chemodosimetric probe for the selective detection of trivalent cations in aqueous medium and live cells. Journal of Photochemistry and Photobiology A: Chemistry 310, 45-51.

10. Datta, B. K., Thiyagarajan, D., Kar, C., Ramesh, A. and Das, G. (2015). A near-infrared emissive Al3+ sensing platform for specific detection in solution, cells and probing DNase activity. Analytica Chimica Acta 882, 76-82.

11. Kar, C., Samanta, S., Goswami, S., Ramesh, A. and Das, G. (2015). A single probe to sense Al(III) colorimetrically and Cd(II) by turn-on fluorescence in physiological conditions and live cells, corroborated by X-ray crystallographic and theoretical studies. Dalton Transactions 44, 4123-4132.

12. Goswami, S., Thiyagarajan, D., Das, G. and Ramesh, A. (2014). Biocompatible nanocarrier fortified with a dipyridinium-based amphiphile for eradication of biofilm. ACS Applied Materials & Interfaces 6, 16384-16394.

13. Samanta, S., Goswami, S., Hoque, M. N., Ramesh, A. and Das, G. (2014). An aggregation-induced emission (AIE) active probe renders Al(III) sensing and tracking of subsequent interaction with DNA. Chemical Communications 50, 11833-11836.

14. Uday, P. S., Thiyagarajan, D., Goswami, S., Adhikari, M. D., Das, G. and        Ramesh, A. (2014). Amphiphile-mediated enhanced antibiotic efficacy and development of a payload nanocarrier for effective killing of pathogenic bacteria. Journal of Materials Chemistry B 2, 5818-5827.

15. Thiyagarajan, D., Goswami, S., Kar, C., Das, G. and Ramesh, A. (2014). A prospective antibacterial for drug-resistant pathogens: A dual warhead amphiphile designed to track interactions and kill pathogenic bacteria by membrane damage and cellular DNA cleavage. Chemical Communications 50, 7434-7436.

16. Datta, B. K., Thiyagarajan, D., Kar, C., Ramesh, A. and Das, G. (2014). A novel chemosensor with visible light excitability for sensing Zn2+ in physiological medium and in HeLa cells. Organic & Biomolecular Chemistry 12, 4975-4982.

17. Kar, C, Samanta, S., Mukherjee, S., Datta, B. K., Ramesh, A. and Das, G. (2014). A simple and efficient fluorophoric probe for dual sensing of Fe3+ and F-: Application to bioimaging in native cellular iron pool and live cell. New Journal of Chemistry 38, 2660-2669.

18. Adhikari, M. D., Mukherjee, S., Saikia, J., Das, G. and Ramesh, A. (2014). Magnetic nanoparticles for selective capture and purification of an antimicrobial peptide secreted by food-grade lactic acid bacteria. Journal of Materials Chemistry B 2, 1432-1438.

19. Samanta, S., Goswami, S., Ramesh, A. and Das, G. (2014). A new fluorogenic probe for solution and intra-cellular sensing of trivalent cations in model human cells. Sensors and Actuators B 194, 120-126.

20. Datta, B. K., Mukherjee, S., Kar, C., Ramesh, A. and Das, G. (2013). Zn2+ and pyrophosphate sensing: Selective detection in physiological conditions and application in DNA-based rapid estimation of bacterial cell numbers. Analytical Chemistry 85, 8369-8375.

21. Kar, C., Adhikari, M. D., Datta, B. K., Ramesh, A. and Das, G. (2013). A CHEF-based biocompatible TURN ON ratiometric sensor for sensitive and selective probing of Cu2+. Sensors and Actuators B 188, 1132-1140. 

22. Basu, A., Thiyagarajan, D., Kar, C., Ramesh, A. and Das, G. (2013). Synthesis, crystal structure and biomolecular interaction studies of pyridine-based thiosemicarbazone and its Ni(II) and Cu(II) complexes. RSC Advances 3, 14088-14098.

23. Goswami, S., Adhikari, M. D., Kar, C., Thiyagarajan, D., Das, G. and Ramesh, A. (2013). Synthetic amphiphiles as therapeutic antibacterials: Lessons on bactericidal efficacy and cytotoxicity and potential application as an adjuvant in antimicrobial chemotherapy. Journal of Materials Chemistry B 1, 2612-2623.

24. Mukherjee, S., Singh, A. K., Adhikari, M.D. and Ramesh, A. (2013). Quantitative appraisal of probiotic attributes and in vitro adhesion potential of bacteriocin producing lactic acid bacteria. Probiotics and Antimicrobial Proteins 5, 99-109.

25. Adhikari, M. D., Goswami, S., Panda, B. R., Chattopadhyay, A. and Ramesh, A. (2013). Membrane-directed high bactericidal activity of gold nanoparticle-polythiophene composite for niche applications against pathogenic bacteria. Advanced Healthcare Materials 2, 599-606.

26. Kar, C., Adhikari, M. D., Ramesh, A. and Das, G. (2013). NIR and FRET-based sensing of Cu2+ and S2- in physiological conditions and in live cells. Inorganic Chemistry 52, 743-752.

27. Kar, C., Adhikari, M. D., Ramesh, A. and Das, G. (2012). Selective sensing and effective separation of Hg2+ from aqueous medium with a pyrene based amphiphilic ligand. RSC Advances 2, 9201-9206.

28. Adhikari, M. D., Das, G. and Ramesh, A. (2012). Retention of nisin activity at elevated pH in an organic acid complex and gold nanoparticle composite. Chemical Communications 48, 8928-8930.

29. Singh, A.K., Mukherjee, S., Adhikari, M. D. and Ramesh, A. (2012). Fluorescence-based comparative evaluation of bactericidal potency and food application potential of antilisterial bacteriocin produced by lactic acid bacteria isolated from indigenous samples. Probiotics and Antimicrobial Proteins 4, 122-132.

30. Vudumula, U., Adhikari, M. D., Ojha, B., Goswami, S., Das, G. and                 Ramesh, A. (2012). Tuning the bactericidal repertoire and potency of quinoline-based amphiphiles for enhanced killing of pathogenic bacteria. RSC Advances 2, 3864-3871.

31. Adhikari, M. D., Panda, B. R., Vudumula, U., Chattopadhyay, A. and Ramesh, A. (2012). A facile method for estimating viable bacterial cells in solution based on “subtractive-aggregation” of gold nanoparticles. RSC Advances 2, 1782–1793.

Group Members

 

Current Graduate Students:

 

Durairaj Thiyagarajan (Doctoral)
Sandipan Mukherjee (Doctoral)
Poulomi Dey (Doctoral)
Priya Mullick (Doctoral)
Basu Bhattacharjee (Doctoral)
Tabassum Sahareen (Masters)

 

Former Graduate Students:

Atul Kumar Singh (Doctoral)
Manab Deb Adhikari (Doctoral)
Sudeep Goswami (Doctoral)
Umakanth Vudumula (Masters)
Shirke Pallavi Uday (Masters)
Vidushi Kapoor (Masters)
Rajanikant Rai (Masters)
Preeti Chauhan (Masters)

 

 
Indian Institute of Technology Guwahati                                                                                                     2013 Department of Biosciences and Bioengineering 
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