Dr. Biman B. Mandal
Assistant Professor
Room: N 107, Department of Biotechnology
Indian Institute of Technology Guwahati
Guwahati - 781 039
Assam, INDIA

E-mail: biman.mandal@iitg.ernet.in
Phone: +91-361-258 2225
Fax: +91 361 258 2249 (O)

URL: http://www.iitg.ernet.in/biotech/Faculty%20Homepage/Biman.htm
 

• Human Tissue Engineering (human tissues/grafts/implants and devices)
• Biomaterials (matrix design and processing)
• Stem cells (matrix and factor guided differentiation)
• Drug delivery systems (scaffolds/hydrogels/nanoparticles/micro-beads)
• In vitro 3D disease models

PhD, Department of Biotechnology, Indian Institute of Technology Kharagpur, India (July 2005 - March 2009).

MSc, Department of Biotechnology, Himachal Pradesh University, Shimla, India (July 2003 - July 2005).

BSc, Presidency College, Calcutta University, Kolkata, India (June 2000 - June 2003). 

Professional experience:
 

June 2011 - Present, Assistant Professor, Department of Biotechnology, IIT Guwahati, INDIA

May 2009 - April 2011, Post Doctoral Research Associate, Department of Biomedical Engineering, Tufts University, Boston, USA.

Awards and Achievements:

1.   The Telegraph, Deccan Herald, Science Daily and Nature India published special research highlight on our silk bone scaffold work published in PNAS 2012.
 

2.   Department of Science and Technology (DST) travel grant award 2012 for attending TERMIS World Congress in Vienna, Austria.
 

3.   Young Scientist Research Grant Award 2011, Department of Atomic Energy (DAE).
 

4.   SYIS Young Investigator Award 2011, Tissue Engineering and Regenerative Medicine International Society - Asia Pacific (TERMIS AP) at International conference, Singapore.
 

5.   Cover Page articles in "PNAS", "Macromolecular Bioscience" and "Biotechnology and Bioengineering" for work on silk based tissue engineering.
 

6.   Delivered an invited talk at MIT, Boston, Department of Material Science and Engineering (Invited by Prof Christine Ortiz).
 

7.   Nature India special research highlight for two of our articles titled "Strong silky scaffold for bone repair" (doi:10.1038/nindia.2012.68) and "Silk route for cancer" (doi:10.1038/nindia.2009.271).
 

8.   Nanotechnology online (Nanotechweb.org) special research highlight titled "Silk sericin nanoparticles behaves as universal drug carriers", 2010 (http://nanotechweb.org/cws/article/lab/40613).
 

9.   Indo-Swiss student exchange award 2006 with full scholarship to work with Prof. Jeffrey Alan Hubbell's group at EPFL, Switzerland.
 

10. Awarded Junior Research Fellowship (JRF) 2005-2007 and Senior Research Fellowship (SRF) 2007-2009 by Council of scientific and Industrial Research (CSIR), India.
 

11. Qualified CSIR-UGC-JRF (Dec' 2004 and June' 2005) All India National Eligibility Test (NET) examination and was qualified for prestigious SPM examination (2005) (Shyama Prasad Mukherjee Scholarship).
 

12. Qualified Graduate Aptitude Test in Engineering (GATE- 2004) with 94.09 percentile and All India Rank of 282.
 

13. Awarded Scholarships from Department of Biotechnology (DBT), Govt. of India (July 2003-June 2005).
 

14. Qualified All India Entrance for Masters in Biotechnology conducted by JNU, 2003.

Member of Professional bodies/Scientific organizations:
 

1. TERMIS - Tissue Engineering and Regenerative Medicine International Society.
2. BMES - Biomedical Engineering Society, USA.
3. SBAOI - Society for Biomaterials and Artificial Organs, India (life member)
4. STERMI - Society for Tissue Engineering and Regenerative Medicine, India (life member)

Reviewer for Journals:

• Biomaterials (JIF 7.8)/ Tissue Engineering (JIF 4.6)/ European Cells and Materials (JIF 5.3)/ Acta Biomaterialia (JIF 4.8)/ Journal of Tissue Engineering and Regenerative Medicine (JIF 3.5).

Invited Lectures delivered:
 

1. MIT, Boston 2011, Department of Material Science and Engineering (Invited by Prof Christine Ortiz).
2. Healthcare India 2012, International conference, New Delhi.
3. ICMPAR 2012, International conference, Rajasthan.
4. Recent Advancements in Microfluidics-2011, Short term course, IIT Guwahati.
    

1. IITG Start Up Grant
2. DAE/BRNS - Young Scientist Research Grant Award
3. ICMR - Grant
    

Manuscripts published in peer reviewed International Journals:

(JIF = Journal Impact Factor 2012, Citations as of August 2012, source Scopus/Google scholar) 

    2012
 

1. Lindsay S. Wray, Jelena Rnjak-Kovacina, Biman B. Mandal, Daniel Schmidt, Eun Seok Gil and David L. Kaplan. A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs. Biomaterials doi: 10.1016/j.biomaterials.2012.09.017.  JIF 7.404

2. Biman B. Mandal, Eun Seok Gil, Bruce Panilaitis and David L. Kaplan. Laminar silk scaffolds for aligned tissue fabrication. Macromolecular Bioscience (DOI = 10.1002/mabi.201200230) JIF 3.886

3. Lee W. Tien, Eun Seok Gil, Sang-Hyug Park, Biman B. Mandal, and David L. Kaplan. Patterned silk fibroin film scaffolds for lamellar bone tissue engineering. Macromolecular Bioscience (DOI: 10.1002/mabi.201200193) JIF 3.886

4. Biman B Mandal, Ariela Grinberg, Eun Seok Gil, Bruce Panilaitis and David L. Kaplan. High strength silk protein scaffolds for bone repair. Proc Natl Acad Sci U S A, 2012; 109:7699-704 JIF 9.771  (Cover page)   [2 citations]

    (Special highlight in The Telegraph, Deccan Herald, Science Daily and Nature India)

5. Sang-Hyug Park, Eun Seok Gil, Biman B. Mandal, Hong Sik Cho, Jonathan A. Kluge, Byoung-Hyun Min and David L. Kaplan. Annulus fibrosus tissue engineering using lamellar silk scaffold. (Journal of Tissue Engineering and Regenerative Medicine, doi: 10.1002/term.541). JIF 3.278   [1 citations]
6. S. C. Kundu, B. Kundu, S. Talukdar, S. Bano, S. Nayak, J. Kundu, Biman B. Mandal, N. Bhardwaj, M. Botlagunta, B. C. Dash, C. Acharya, and A. K. Ghosh. Non-mulberry silk biopolymers for tissue engineering, regenerative medicine and biotechnological uses. Biopolymers, 2012; 97:455-467.  JIF 2.870   [3 citations]
    

7. Sang-Hyug Park, Eun Seok Gil, Hong Sik Cho, Biman B. Mandal, Lee W. Tien, Byoung-Hyun Min and David L. Kaplan. Intervertebral disc tissue engineering using biphasic silk composite scaffolds. Tissue Engineering part A, 2012; 447-458.   JIF 4.022   [3 citations]

    2011

8. Biman B. Mandal, Sang-Hyug Park, Eun Seok Gil and David L. Kaplan. Stem cell based meniscus tissue engineering. Tissue Engineering A, 2011; 17:2749-2761. JIF 4.022 [2 citations]

9. Sang-Hyug Park, Hong Sik Cho, Eun Seok Gil, Biman B. Mandal, Byoung-Hyun Min and David L. Kaplan. Silk-fibrin/hyaluronic acid composite gels for nucleus pulposus (NP) tissue regeneration. Tissue Engineering A, 2011; 17:2999-3009.   JIF 4.022   [3 citations]
10. Biman B. Mandal, Borna Ghosh and S. C. Kundu. Non-mulberry silk sericin/poly (vinyl alcohol) hydrogel matrices for potential biotechnological applications. International J. Biological Macromolecules 2011; 49:125-33. JIF 2.453   [5 citations]
11. Biman B. Mandal, Sang-Hyug Park, Eun Seok Gil and David L. Kaplan. Multilayered silk scaffolds for meniscus tissue engineering. Biomaterials, 2011; 32:639-51. JIF 7.404  [12 citations]

   2010

12. Eun Seok Gil, Biman B. Mandal, Sang-Hyug Park, Jeff Marchant, Fiorenzo Omenetto and David L. Kaplan. Helicoidal Multi-Lamellar Features of RGD-functionalized Silk Biomaterials for Corneal Tissue Engineering. Biomaterials, 2010; 31:8953-63. JIF 7.404     [15 citations]

13. Biman B. Mandal, Soumen Das, Koel Choudhury and S. C. Kundu. Implications of silk film RGD availability and surface roughness on cytoskeletal organization and proliferation of primary rat bone marrow cells. Tissue Engineering A, 2010; 16:2391-403. JIF 4.022    [6 citations]
     

14. Biman B. Mandal and S. C. Kundu. Biospinning by silkworms: Silk fiber matrices for tissue engineering applications. Acta Biomaterialia, 2010; 6:360-71. JIF 4.865    [16 citations]

   2009

15. Biman B. Mandal and S. C. Kundu. Calcium alginate bead embedded in silk fibroin as 3D dual release scaffolds. Biomaterials, 2009; 30:5170-5177. JIF 7.404   [23 citations]
     

16. Biman B. Mandal and S. C. Kundu. Osteogenic and adipogenic differentiation of rat bone marrow cells on mulberry and non-mulberry silk gland fibroin 3D scaffolds. Biomaterials, 2009; 30:5019-5030. JIF 7.404        [14 citations]
     

17. Biman B. Mandal, Sonia Kapoor and S. C. Kundu. Silk fibroin/polyacrylamide semi-interpenetrating network hydrogels for controlled drug release. Biomaterials, 2009; 30:2826-2836. JIF 7.404       [45 citations]
     

18. Biman B. Mandal and S. C. Kundu. Cell proliferation and migration in 3D silk fibroin scaffolds. Biomaterials, 2009; 30:2956-2965. JIF 7.404      [69 citations]
     

19. Biman B. Mandal and S. C. Kundu. Non-mulberry silk gland fibroin 3D scaffold for enhanced differentiation of human mesenchymal stem cells into osteocytes. Acta Biomaterialia, 2009; 5:2579-2590. JIF 4.865       [11 citations]
     

20. Biman B. Mandal, Anjana S. Priya and S. C. Kundu. Novel silk sericin-gelatin 3D scaffolds and 2D films: Fabrication and characterization for potential tissue engineering applications. Acta Biomaterialia, 2009; 5:3007-3020. JIF 4.865      [30 citations]
     

21. Biman B. Mandal and S. C. Kundu. Self assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery applications. Nanotechnology, 2009; 20:355101. (Most downloaded article in a week’s time as per Nanotechweb site). JIF 3.979      [15 citations]
     

22. Biman B. Mandal, Jasdeep K. Mann and S. C. Kundu. Silk fibroin/gelatin multilayered films as a model system for controlled drug release. European Journal of Pharmaceutical Sciences, 2009; 37:160-171. JIF 3.212      [18 citations]
     

23. Biman B. Mandal, Tamal Das, S. C. Kundu. Non-bioengineered silk gland fibroin micromolded matrices to study cell-surface interactions. Biomedical Microdevices, 2009; 11:467-476. JIF 3.032      [10 citations]
     

24. Biraja C. Dash*, Biman B. Mandal* and S. C. Kundu. Silk gland sericin protein membranes: fabrication and characterization for potential biotechnological applications. Journal of Biotechnology, 2009; 144:321-9. (* equal contribution). JIF 3.045   [13 citations]

   2008

25. Biman B. Mandal and S. C. Kundu.  A novel method for dissolution and stabilization of non-mulberry silk gland protein fibroin using anionic surfactant sodium dodecyl sulfate. Biotechnology and Bioengineering, 2008; 99:1482-1489. JIF 3.946   [22 citations]
     

26. Biman B. Mandal and S. C. Kundu. Non-bioengineered silk gland fibroin protein: Characterization and evaluation of matrices for potential tissue engineering applications. Biotechnology and Bioengineering, 2008; 100:1237-1250 (Cover page article).  JIF 3.946   [29 citations]
     

27. Biman B. Mandal and S. C. Kundu. Non-bioengineered silk fibroin protein 3D scaffolds for potential biotechnological and tissue engineering applications. Macromolecular Bioscience, 2008; 8: 807-818 (Cover page article).   JIF 3.886   [42 citations]

Manuscripts in preparation:
 

28. Biman B Mandal, Sang-Hyug Park, Eun Seok Gil, Bruce Panilaitis and David L. Kaplan. Mimicking native annulus fibrosus 30^o cross angle ply architecture in a silk intervertebral disc model.
29. Biman B. Mandal and David L. Kaplan. A novel single step method for micron range silk fiber production and its tissue engineering applications.
30. Biman B Mandal, Bruce Panilaitis, Fiorenzo Omenetto and David L. Kaplan. Hierarchical assembly of patterned porous angle-ply silk laminates for aligned tissue fabrication.
31. Biman B. Mandal, Eun Seok Gil, Fiorenzo Omenetto, James Funderburgh and David L. Kaplan. Transparent silk corneal stromal equivalents using corneal stem cells.
32. Eun Seok Gil, Sang Hyug Park, Biman B. Mandal, Xiao Hu, Lee Tien and David L. Kaplan. Silk/collagen biomaterials for controlling Mesenchymal Stem Cells (MSC) differentiation to osteogenesis and adipogenesis.
33. Eun Seok Gil, Ty E. Harkness, Sang Hyug Park, Biman B. Mandal and David L. Kaplan. The effect of water-annealing and methanol stabilization methods on the structure and properties of silk biomaterials.

1. Biman B. Mandal and David L. Kaplan. Multilayered silk scaffolds for meniscus tissue engineering. (Provisional US patent application number 61/352,937).

2. Biman B. Mandal and David L. Kaplan. High strength silk protein scaffolds. (Provisional US patent application number 61/621,209).
    
3. Biman B. Mandal and David L. Kaplan. A method to fabricate native like annular fibrosus (AF) region of intervertebral disc. (US patent filed, application in process).
    

     1.    Biman B Mandal and David L. Kaplan.  Biologic biomaterials: Silkworm silk. The Biomedical Engineering Handbook (Biomaterials
           section) edited by J.D. Bronzino and Donald R. Peterson. (Invited book chapter).
 

1. Biman B Mandal, A. Grinberg, E. S. Gil, B. Panilaitis, David L. Kaplan. High strength silk protein scaffolds for bone repair. 3^rd TERMIS World Congress 2012, Vienna, Austria, September 05-08, 2012.
2. J. Rnjak-Kovacina, L. S. Wray, Biman B. Mandal, E. S. Gil, A. S. Weiss, David L. Kaplan. Versatile biomaterial scaffold platform for critical-sized tissue construct. 3^rd TERMIS World Congress 2012, Vienna, Austria, September 05-08, 2012.
3. Lindsay S. Wray, Jelena Rnjak-Kovacina, Biman B. Mandal, Xiao Hu, David L. Kaplan. Versatile biological scaffolding platform for building critically-sized tissue constructs containing nutrient delivery conduits. The 7th Symposium on Biologic Scaffolds for Regenerative Medicine, Napa Valley, CA.
4. Biman B. Mandal, S. H. Park, E. S. Gil, David L. Kaplan. Hierarchical silk scaffolds for Intervertebral disc engineering. Oral talk at TERMIS AP, 2011, Singapore, August 3-5, 2011.
5. Biman B. Mandal and David Kaplan. Hierarchical silk laminates for tissue formation. Poster presented at BMES conference, Austin, Texas, USA, October 6-9, 2010.
6. L. W. Tien, E. S. Gil, S. H. Park, Biman B. Mandal and David L. Kaplan. Patterned silk film scaffolds for lamellar bone tissue engineering. Poster, BMES conference, Austin Texas, USA, October 6-9, 2010.
7. Biman B. Mandal, S. H. Park, E. S. Gil and David Kaplan. Multilayered silk scaffolds for meniscus tissue engineering. Oral talk at TERMIS EU 2010, Ireland, June 13-17, 2010.
8. E. S. Gil, Biman B. Mandal, S. H. Park, J. Merchant, F. Omenetto and David Kaplan. Corneal Tissue Engineering Using Patterned and Porous Silk Films. Poster presented at 2^nd Termis World Conference, Seoul, Korea, August 31- September 3, 2009.
    

9. C. Acharya, R. Dash, Biman B. Mandal, J. Kundu, N. Bharadwaj, S. Nayak, S. Talukdar, M. Dewan and B. Kundu and S. C. Kundu. Non-mulberry Silk Proteins: Advanced Natural Biomaterial for Tissue Engineering and Drug Delivery. Oral presentation at 2^nd Termis World Conference, Seoul, Korea, August 31- September 3, 2009.
    

10. Biman B. Mandal and S.C. Kundu. Self assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery. Invited lecture at 3^rd Indo-Australian Conference on Biomaterials, Implants, Tissue engineering and Regenerative Medicine, Australia, January 14-16, 2008.
11. Biman B. Mandal and S. C. Kundu. Silk proteins fibroin and sericin of non-mulberry tropical tasar silkworm Antheraea mylitta as potential biopolymers for tissue engineering. Oral and poster presented at International conference on Biomaterials and Tissue Engineering for Biotechnological Applications (BTEB 2008), IIT Kharagpur, India, November 22-24, 2008.
12. Biman B. Mandal, Chitrangada Acharya, Rupesh Dash, Joydip Kundu and S. C. Kundu. Non-mulberry silk fibroin protein as biomaterial. Presented as an invited lecture at International conference on "Fibrous proteins", Australia, March 31-April 2, 2008.
13. Biman B. Mandal, Anjana S. Priya and S. C. Kundu. Novel silk protein sericin-gelatin 2D films and 3D scaffolds: Fabrication, characterization and optimization for potential tissue engineering applications. Oral presentation at International Conference on Cellular and Molecular Bioengineering, Singapore, December 10-12, 2007.
14. Chitrangada Acharya, Rupesh Dash, Biman B. Mandal, Joydip Kundu, S. C. Kundu. Presented as an invited lecture at International workshop on Cell based tissue engineering using natural polymers (Silk: Medical applications), Gwangju Institute of Science and Technology, Gwangju, Korea, November 28-29, 2007.
15. Chitrangada Acharya, Rupesh Dash, Biman B. Mandal, Joydip Kundu, S. C. Kundu. Silk protein matrices for cell-based biomedical applications. Presented as an invited lecture at International conference on "Future trends in composite materials and processing", IIT Kanpur, India, December 12-14, 2007.
16. Participated in 7^Th Indo-US Flow Cytometry Workshop on "Proliferation, Apoptosis and Signal Transduction", School of Biotechnology, JNU, New Delhi, February, 10-14, 2007.
17. Participated in International Conference on "Animal models in Stem Cells", EPFL, Switzerland, December 15, 2006.
18. Participated in National Conference on "Biomaterial, Tissue Engineering and Medical Diagnostics- 2006" at IIT Delhi, February 24-26, 2006.

1. Ms. Salma Jasmine (PhD Student)
    
2. Mr. Manishekhar Kumar (PhD Student)
    
3. Mr. Jadi Praveen Kumar (PhD Student)
    
4. Mr. C. S. Krishna Murthy (PhD Student)
    
5. Mr. Saket Kumar Singh (MTech Student)