Contact
Research
interests
Academic
Projects
Publications
Book chapters
Conferences
Workshops
Students & Staff
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Contact |
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Dr. Senthilkumar Sivaprakasam
Assistant Professor,
Room no.8,
Department of Biotechnology,
Indian Institute of Technology Guwahati
Guwahati, Assam – 781 039
Tel: +361-2582226 (O)
Fax: +91 361 258 2249 (O)
Email: senthilkumar@iitg.ernet.in
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Research
interests |
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Biocalorimetry (bench-scale and large-scale biocalorimeters)
Bio-Process Analytical Technology (BioPAT) (synthesis of recombinant
proteins and value-added bioproducts)
Real-time monitoring and control of bioprocess systems (Biocalorimetry,
Dielectric Spectroscopy and Exhaust Gas Analyzer)
Mathematical modelling of bioprocess systems
Monitoring and control of environmental bioprocess systems leading
to value-added products
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Academic |
Background:
Ph.D (Biochemical Engineering), Central Leather Research
Institute, Chennai, India.
(2002 - 2007)
M.Tech. (Chemical
Engineering), Chemical Engineering Department, Coimbatore
Institute of Technology, Coimbatore, India.
(2000 - 2002)
B.E. (Chemical
Engineering), Chemical Engineering Department, Annamalai
University, India
(1996 - 2000)
Professional Experience:
June 2011
onwards: Assistant Professor, Biotechnology Department, Indian
Institute of Technology, Guwahati, India
Oct 2010 - May 2011:
Research Assistant, Laboratory of Integrated Bioprocessing, Dublin
City University (DCU), Ireland
Sep 2008 - Sep 2010:
IRCSET Post Doctoral Fellow, Laboratory of Integrated Bioprocessing,
Dublin City University (DCU), Ireland
Sep2007 - April2008:
AIST Post Doctoral Fellow, Environmental Science Centre, The
University of Tokyo, Japan
June 2007 - August 2007:
Group Leader, API-Pilot Plant Division, Torrent Pharmaceuticals
Ltd, Ahemedabad, India.
List of
Awards:
National
 Senior Research Fellowship of
the Council for Scientific and Industrial Research, New Delhi, India
(2003 to 2007)
Junior Research Fellowship of the
University Grants Commission, New Delhi, India, 2002.
International
Irish Council for Scientific and Engineering and Technology (IRCSET)
‘EMPOWER’ postdoctoral fellowship award (2008-2010)
Advanced
Industrial Science and Technology (AIST) post doctoral research
fellowship award, (2007 – 2008)
List of Honours:
Won first prize for best case
study presentation in ‘Master Course on Bioprocess Engineering’
organized by European Federation of Biotechnology,
Croatia (2010).
VISAL award of Indian Institute
of Chemical Engineers (IICHE) for best oral presentation, “A
calorimetric study on the biological activity of P. aeruginosa
cultivated in a substrate-limited growth media” at
SCHEMCON’06
Journal reviewing:
Biotechnology and Bioengineering
Biochemical Engineering
Journal
Environmental Science and
Technology
Journal of Thermal
Analysis and Calorimetry
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Projects |
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List of Publications
in Peer-reviewed Journals |
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1. M. M.
Schuler, S. Senthilkumar, B.Freeland and Ian W. Marison,
Application of feed-back control based on metabolic heat flow rate
measurements for fed-
batch bioprocess systems. Applied Microbiology
and Biotechnology (Under Review)
2. S. Senthilkumar, M. M. Schuler, A. Hama, K.
Hughes and Ian W. Marison, Biocalorimetry: A Robust PAT Tool for
In-line Monitoring and Control of Aerobic
Fed-Batch Cultures of Yeast Cells, Journal of
Thermal Analysis and Calorimetry, doi: 10.1007/s10973-010-1259-x.
3. Senthilkumar S, Balaji D and S. Mahadevan
(2010) Optimization studies on production of a halo-tolerant
protease from Pseudomonas aeruginosa strain
BC1 and its application on tannery saline
wastewater treatment. Brazilian Journal of Microbiology (Article in
Press)
4. Balaji D, Senthilkumar S and S. Mahadevan
(2010). Batch Kinetic Studies on Growth of Salt Tolerant
Pseudomonas aeruginosa Secreting Protease in a
Biocalorimeter, Biotechnology and Bioprocess
Engineering, 2010, volume 15, number 4, 670-675.
5. Sudharshan S, Senthilkumar S, and S Mahadevan
(2009). Investigations on ultraviolet light and nitrous acid induced
mutations of halotolerant bacterial
strains for the treatment tannery soak liquor,
International Biodeterioration and Biodegradation 63: 176-181.
6. Senthilkumar S, S. Mahadevan, and Sudharshan S
(2008). Calorimetric online monitoring of proteolytic activity of
P.aeruginosa cultivated in a bench-scale
biocalorimeter, Biochemical Engineering Journal,
39:149-156.
7. Senthilkumar S, S. Mahadevan, and S. Rajakumar.
(2008). Biocalorimetric studies on the metabolic activity of
P.aeruginosa aerobically grown in a
glucose-limited complex growth media. Bioscience,
Biotechnology and Biochemistry, 72:936-42.
8. Senthilkumar S, S. Mahadevan, S. Gopalraman
(2008). Oxygen mass transfer studies on batch cultivation of P.
aeruginosa in a biocalorimeter, Electronic
Journal of Biotechnology, 11(1).
9. Senthilkumar S, S. Mahadevan, S. Gopalraman.
(2008). Biocalorimetric and respirometric studies on biological
treatment of tannery saline wastewater,
Applied Microbiology and Biotechnology. 78(2):
249-255.
10.Senthilkumar S, S. Mahadevan, S. Sekar, S. Gopalraman.
(2008) Batch studies on biological treatment of tannery saline
wastewater by identified
halotolerant bacterial strains, Microbial Cell
Factories, 7:1-7.
11.Senthilkumar S, S. Mahadevan, S. Gopalraman. (2007).
Isolation, Identification and optimization of halotolerant bacteria
for the degradation of tannery
saline wastewater, Research Journal of
Biotechnology, 2: 5 -11.
12.Senthilkumar S, S. Mahadevan and M. Battacharya (2007).
Biocalorimetric and respirometric studies on metabolic activity of
aerobically grown batch
culture of Pseudomonas aeruginosa,
Biotechnology and Bioprocess Engineering, 12: 340-347.
13.Sudharshan S, Senthilkumar S* and K Ranjith, Physical and
nutrition factors affecting the production of amylase from bacillus
species isolated from
spoiled food waste, African Journal of
Biotechnology, 6: 430-435. (*Corresponding author)
Under Preparation:
S. Senthilkumar,
M. M. Schuler, B.Freeland and Ian W. Marison Bench scale
calorimetry, as a real time analytical tool for monitoring
animal
cell cultivation
process – Invited article from Biotechnology
Journal
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Book Chapter: |
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1. Ian W. Marison, Senthilkumar Sivaprakasam, Moira Monika Schuler,
Edited Book Title: Industrial Control Systems Chapter Title: Process
Analytical
Technology (PAT) as a key component for industrial control
systems; a holistic approach to Quality by Design. Nova Science
Publishers Inc.
( www.novapublishers.com), NY, USA – In Press
2. Ian W. Marison, Senthilkumar Sivaprakasam, Moira Monika Schuler,
S.Hennessy and B.Freeland Current status of monitoring
technologies for the
purposes of PAT in bio processing , Invited Book
chapter from Springer Publishers – Under preparation
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List of
Conferences (* denotes presenter): |
1. Marison I, Senthilkumar S, Schuler MM*
Bioprocess monitoring and control for high cell density cultures.
Proceedings of 8th European Symposium on
Biochemical Engineering Science, Bologna,
Italy.
2. Senthilkumar S* (2010). ‘Master Course on
Bioprocess Engineering’ organized by European Federation of
Biotechnology, Croatia. Poster presentation
on ‘Biocalorimetric monitoring of fed-batch
bioprocess systems’, Proceedings of European Bioprocess Engineering
Course.
3. Senthilkumar S*, Schuler MM and Marison I
(2010). Biocalorimetry: A Robust PAT Tool for In-line Monitoring and
Control of Aerobically Grown Fed-Batch
Cultures of Kluyveromyces marxianus.
Proceedings of XVI International Society for Biological Calorimetry
(ISBC) Conference, Santiago Compostela,
Spain.
4. Schuler MM*, Senthilkumar S, and Marison
I (2010). On-line data reconciliation based on energy balances
enhances the potential of biocalorimetry as a
PAT process analyser. Proceedings of 8th
European Symposium on Biochemical Engineering Science, Bologna,
Italy.
5. Freeland B, Senthilkumar S, Schuler MM*
and Marison I (2010) Application of metabolic heat flow measurements
using ANNs for in-line monitoring and
control of bioprocess systems. Proceedings
of 8th European Symposium on Biochemical Engineering Science,
Bologna, Italy.
6. Freeland B*, Senthilkumar S, Schuler MM
and Marison I (2010) ANN model for the prediction of overall heat
transfer coefficient in pilot scale bioreactors
for non newtonian fluids. Proceedings of XVI
International Society for Biological Calorimetry (ISBC) Conference,
Santiago Compostela, Spain.
7. Senthilkumar Sivaprakasam* and Ian
Marison, Progress and challenges on design of high sensitivity
biocalorimeter (BioRC1) for in-line bioprocess
monitoring, 13th European Congress on
Biotechnology, Barcelona, Spain. New Biotechnology, Volume 25,
Supplement 1, September 2009, Pages S325-
S326
8. M. Izumo*, Senthilkumar S, M. Arai, K.
Ishikawa, Y. Nakayama "A comparative study on impact sensitivity of
explosive materials at low temperature
conditions" ISEM2008: 3rd International
Symposium on Energetic Materials and their Applications, Tokyo,
4/24-25 (2008)
9. Senthilkumar S*, Mahadevan S and Marison
I (2010) Application of Real Time Metabolic Heat Flow Measurements
to Characterize Physiological
behaviour of Salt-Tolerant Batch Cultures of
Pseudomonas aeruginosa. Proceedings of XVI International Society
for Biological Calorimetry (ISBC)
Conference, Santiago Compostela, Spain.
10. Senthilkumar Sivaprakasam*, Surianarayanan
Mahadevan, Swaminathan Gopalraman “Biocalorimetry- An Online tool
for assessing microbial activity
on industrial wastewater treatment” at
Southeast Asian Natural Resources and Environment Management
(SANREM’06) conference held at SABAH,
Malaysia.
11. Senthilkumar Sivaprakasam*, Surianarayanan
Mahadevan, Swaminathan Gopalraman “Application of Reaction
Calorimetry for monitoring the biological
treatment of tannery saline
wastewater” at International Conference on Cleaner Technologies and
Environmental Management (ICCTEM’07) held at
Pondicherry Engineering College,
Pondicherry.
12. Senthilkumar Sivaprakasam*, Surianarayanan
Mahadevan, Swaminathan Gopalraman “Calorimetry monitoring of
biochemical reactions” at
International Conference for Biotechnology
Engineering (ICBioE’07) held at University of Malaysia, Kulalampur.
13. Senthilkumar Sivaprakasam*, Surianarayanan
Mahadevan, Susheela Rajakumar and Swaminathan Gopalraman
“Biocalorimetric studies on biological
treatment of soak liquor” in
CHEMCON’03, at RRL, Bhubaneswar.
14. Senthilkumar Sivaprakasam, Karunasena Ranjith*,
Surianarayanan Mahadevan, Swaminathan Gopalraman “A calorimetric
study on the biological
activity of P.aeruginosa cultivated in a
substratelimited growth media” at SCHEMCON’06 co-organized by
Anantapur University and IICHE at Anatapur.
15. Sudharshan Sekar*, Senthilkumar Sivaprakasam,
Surianarayanan Mahadevan, Swaminathan Gopalraman “Isolation,
Identification and
Characterization of Protease from P.aeruginosa
identified from tannery soak liquor” at Faculty of Engg. &
Technology, Bharatidasan University, Trichy.
16. Senthilkumar Sivaprakasam*, Surianarayanan
Mahadevan, Swaminathan Gopalraman “Biocalorimetric and biokinetic
studies on growth of
P.aeruginosa in substrate limited growth media” in
CHEMCON’06 held at GNFC, Ankleshwar, Gujarat.
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List of Workshops |
1. S. Senthilkumar, M. M. Schuler and I.W. Marison (Jan
2011). Poster presentation, Biocalorimetry as a monitoring tool for
biological systems, WE Heraeus
Seminar, Workshop on Biothermodyanamics, 472, Bad Honnef,
Germany.
2. Senthilkumar S (2010). ‘Master Certficate Course on
Bioprocess Engineering’ organized by European Federation of
Biotechnology, Croatia.
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Students
& Staff |
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