Department of Biosciences and Bioengineering 
                    
Indian Institute of Technology Guwahati

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Department of  Biosciences and Bioengieering
Indian Institute of Technology Guwahati
Guwahati 781039

Telephone:
(0361) 258-2250
Fax: (0361) 258-2249
E-mail: biooff@iitg.ernet.in

 
Dr. Manish Kumar, Ph.D.

Associate Professor


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Dr. Manish Kumar
Associate Professor
Office Room # 108, N-Block
Indian Institute of Technology Guwahati
Guwahati, Assam - 781 039


E-mail: mkumar1@iitg.ernet.in / manishvet@gmail.com
Phone: +91-7896003715 (Mobile)
+91 361-2582230 (office)
Fax: +91 361 258 2249 (O)

Research Interests

1. Molecular interaction of host-pathogen-vector of infectious diseases
2. Gene expression analysis of Spirochete, Leptospira interrrogans and Borrelia burgdorferi
3. Development of vaccine against outer membrane protein of Leptospira interrogans and Borrelia
    burgdorferi
.
4. Vector borne diseases of Zoonotic importance.

Academics

Education
 

        Govind Ballabh Pant University of Agriculture and technology, Pantnagar, College of Veterinary Sciences, Uttaranchal, India, B.V.Sc. & A.H. (1999-2004).

 

         Indian Veterinary Research Institute, Izatnagar, Bareilly, India, Veterinary Public Health M.V.Sc. (2004- 2006).

 

         University of Maryland, College Park, USA, Molecular Microbiology and immunology PhD. (2006-2010).

 

Professional Experience

 

         Johns Hopkins School of Medicine, Baltimore, USA, Division of Rheumatology, Postdoctoral fellow (Jan 2011- May 2012).

 

         Assistant Professor, Department of Biosciences and Bioengineering, IIT Guwahati (June 2012-  Jan 2017)

 

Achievements & fellowships:

2010              Avrum Gudelsky Veterinary Graduate Student Award for exemplary graduate
                     research in Veterinary Medicine, College Park, Maryland, USA.

2006              Graduate Research Assistantship, University of Maryland, College Park, USA.

2004              Junior Research Fellowship (JRF) of Indian Council of Agriculture Research, New
                     Delhi, India.

1999              National Talent Scholarship (NTS) of Indian Council of Agriculture Research, New
                     Delhi, India.

Professional affiliations:

    1. Member of Indian Association of Veterinary Public Health Specialists (IAVPHS).

 

    2. Member of Indian Society for Veterinary Medicine (ISVM)

 

    3. Member of American Society for Microbiology (ASM).

 

    4. Registered Veterinary Practitioner, Veterinary Council of India (VCI), New Delhi.

 

    5. Registered Veterinary Practitioner, Bihar Veterinary Council, Patna, India.

 

    6. Member of the Indian Science Congress Association, Kolkata, India.

 

    7. Member of Society for Biosafety, Bhopal, India

 

Publications

 

1.     Ghosh KK, Prakash A, Balamurugan V, Kumar M. (2017). Catecholamine modulated novel surface exposed adhesin LIC20035 of Leptospira binds host extracellular matrix components and is recognized by host during infection. Applied and Environmental Microbiology (Accepted).

2.      Singh P, Verma D, Backstedt BT, Kaur S, Kumar M, Smith AA, Sharma K, Yang X, Azevedo JF, Gomes-Solecki M, Buyuktanir O, Pal U. (2017). Borrelia burgdorferi BBI39 paralogs are targets of protective immunity inducing microbicidal responses and reducing pathogen persistence either in hosts or in the vector. J Infect Dis.  Jan 31. doi:10.1093/infdis/jix036.

3.      Dixit B, Ghosh KK, Fernandes G, Kumar P, Gogoi P, Kumar M (2016). Dual nuclease activity of a Cas2 protein in CRISPR-Cas subtype I-B of Leptospira interrogans. FEBS Lett; 590 (7): 1002-16.

4.      Kumar P, Pandian S J, Kumari RK, Kumar M. (2016). Package and practices for Livestock Farmers: Under supervision of a Veterinarian. Poulvet;Online journal http://poulvet.com/dairy/articles/livestock_farmers.php

 

5.      Kumar P, Pandian SJ, Sinha BS, Kumari RK, Kumar M. (2016).Calf Diarrhoea: Devastating disease of bovine during first three months after birth. http://www.krishisewa.com/articles/livestock/705-calf-diarrhoea.html

 

6.      Kumar P, Roy RK, Kumar M, Kumari RK, Kumar A. (2015).PPR control in Goat: A guide for animal health service providers. http://www.vethelplineindia.co.in/ppr-control-in-goat-a-guide-for-animal-health-service-providers/

 

7.      Kumar P, Kumari RK, Kumar M, Kumar S, Chakrabarti A. (2014). “Current practices and research updated on Diabetes mellitus in Canine” Veterinary World 7(11): 952-959.

 

8.      Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard MV.(2012). “Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi” BMC Microbiology; 44 (12) doi:10.1186/1471-2180-12-44.

 

9.      Kumar M, Kaur S, Kariu T, Yang X, Bossis I, Anderson JF, Pal U. (2011)."Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccines” Vaccine; 29 (48): 9012– 9019.

 

10.  Xiao S*, Kumar M*, Yang X, Akkoyunlu M,Collins PL, Samal SK, Pal U. (2011) “An efficient avian host-restricted viral vector for antigen-specific host immunization against Lyme disease pathogens” Vaccine; 29 (32):5294-303. (* equal contribution)

 

11.  Kumar M, Bhilegaonkar KN, Agarwal RK. (2011). “Prevalence and characterization of rotavirus from faecal samples of children and animals” Indian Journal of Animal Sciences; 81(10): 993–999.

 

12.  Kumari, R.R; Kumar, Manish and Kumar, P. (2011). An Integrated Approach to Control Toxocara vitulorum: A Major Cause of Buffalo Calf Mortality. Livestock International; 15 (2):8-9.

 

13.  Kumar M, Yang X, Coleman AS, Pal U. (2010). “BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts” J Infect Dis; 201 (7): 1084-1095

14.  Zhang X, Yang X, Kumar M, Pal U. (2009) “BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle”. J Infect Dis; 200 (8):1318-30.

15.  Promnares K, Kumar M, Shroder DY, Zhang X, Anderson JF, Pal U.(2009) “Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice”. Mol Microbiol; 74 (1):112-25.

16.  Ouyang Z, Kumar M, Kariu Toru, Haq S, Goldberg M, Pal U, Norgard M V. (2009). “BosR (BB0647) governs virulence expression in Borrelia burgdorferi”.  Mol Microbiol; 74(6):1331-43

 

17.  Kumari, R R; Kumar Pankaj and Kumar, Manish. (2009). Nutritional Deficiency Diseases of Newborn Farm Animals and There Management. Intas Polivet Vol 10 (2)

18.  Pal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson JF, Fikrig E. (2008) “A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks”. J Infect Dis; 197 (1):148-55.

19.  Coleman AS, Yang X, Kumar M, Zhang X, Promnares K, Shroder D, Kenedy MR, Anderson JF, Akins DR, Pal U.(2008). “Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity”. PLoS ONE; 3 (8):3010e

20.  Kumar, Pankaj; Challa, J; Dimri, U & Kumar, Manish. (2007). Role of Micro-nutrients in dermatological disorders of dog. Intas Polivet. Vol 8 (2): 465-471.

 

21.  Kumar, Manish; Bhilagaonkar, K.N. and Kumar Pankaj. (2006). Epidemiology of Japanese Encephalitis in the Indian Scenario. Intas Polivet, 7 (II): 312-319.

 

22.  Kumar, Pankaj; Kumar, Manish; Mudgal, V & Mishra, S.K. (2005) “Awareness for nutritional management in Pet animals”. Pet India, Vol.11 (6): 48-50.

 

23.  Kushwaha R.B.; Shankar Uma; Kumar Pankaj & Kumar Manish. (2005). “Pyometra in canines: an appraisal” Poulvet .Online in www.poulvet.com/articles/ pyometra_article.

 

24.  Kumar, Pankaj; Kumar, Manish; Prasanna, S.B & Singh, S.K. (2004). “First Aid   assistance for   companion animal during emergency” Pet India, Vol.10 (12): 15-17.

 

Conferences and Presentations:

 

1.     Kumar M. (2017).Immunogenic Lipoprotein LP46 of Leptospira interrogans interacts with   host extracellular  matrix components.Opportunities and Challenges of Translational Research in the Frontier Areas of Animal Biotechnology, OUAT National seminar, Bhubaneswar.

2.      Kumar M. (2017). Analysis of Differential Expression of Outer Membrane Proteins of pathogenic Leptospira in response to catecholamine: a host stress factor. ICAR-NIVEDI meeting, Bengaluru.

3.      Dixit B, Kumar M. (2016).Characterization of one of core Cas protein of CRISPR-Cas Subtype I-B in Leptospira interrogans Copenhageni strain Fiocruz L1-130. Innovative Research in Biotechnology, Biomedical Sciences, Bioinformatics and Stem Cell application in JNU, New Delhi. (Best Poster award)

4.      Dixit B, Kumar M. (2016). Characterization of Cas1 protein of CRISPR Cas subtype I-B Leptospira interrogans Copenhageni strain Fiocruz L1-130. Global Symposium on “Animal Health: Newer Technologies and their Applications” in Veterinary College Khanapara

 

5.      Kumar P, Pandian SJ, Sinha BS, Kumari RK, Kumar M. (2016).Calf Diarrhoea: Devastating disease of bovine during first three months after birth. http://www.krishisewa.com/articles/livestock/705-calf-diarrhoea.html

 

6.      Ghosh K K, Kumar M. (2016). In vitro expression analysis of selected outer membrane proteins of Leptospira interrogans Copenhageni strain Fiocruz L1-130 for diagnostics and vaccination. Global Symposium on “Animal Health: Newer Technologies and their Applications” in Veterinary College Khanapara.

 

7.      Prakash A, Kumar M. (2016). Characterization of a novel Cas5 protein of CRISPR-Cas type I-B in pathogenic Leptospira interrogans. 57th Annual Conference of Association of  Microbiologists of India and International symposium on “Microbes and Biosphere” in Gauhati University, Assam.

 

8.      Ghosh K K, Kumar M. (2016). Modulation of gene expression of Leptospira interrogans exposed to catecholamines and its role in host immune evasion. 57th Annual Conference of Association of Microbiologists of India and International symposium on “Microbes and Biosphere” in Gauhati University, Assam.

 

9.      Basumatary B, Kumar M. (2016). Investigation of biochemical characteristics of a core Cas protein in CRISPR-Cas subtype-IC in Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130. 57th Annual Conference of Association of Microbiologists of India and  International symposium on “Microbes and Biosphere” in Gauhati University, Assam.

 

10.  Dhara A, Kumar M. (2016). Cloning, expression and purification of Caseinolytic proteases of pathogenic Leptospira interrogans Copenhageni strain Fiocruz L1-130. 57th Annual Conference of Association of Microbiologists of India and International symposium on “Microbes and Biosphere” in Gauhati University, Assam

 

11.  Dixit  B, Kumar M. (2015). A novel Cas2 Protein of CRISPR/Cas system in Leptospira interrogans displaying dual nuclease activity.9th Scientific meeting of International Leptospirosis society,7-10 Oct, 2015 Semarang, Indonesia.

 

12.  Ghosh K K, Kumar M (2015). Characterization of hypothesized outer membrane protein of Leptospira interrogans Copenhageni. 8th Indo Global summit and Expo on Vaccines,Therapeutics & healthcare, November 02-04, 2015 HICC, Hyderabad, India.(Best Posteraward)

 

13.  Kung F, Kumar M, Promnares K, Yang X, Pal U (2014). Role of bbd18 in Borrelia burgdorferi Biology and Infectivity. Graduate Research Interaction Day (GRID). College Park, Maryland, USA.

14.  Soloski M J,  Kumar M, Wu G, Ji H, Kortte K, Crowder L,  Aucott J. (2012). Immune Profiling of Early Lyme Disease. ID Week, 17-21 oct,2012  San Diego, California, USA.

15.  Kumar, Pankaj, Sharma, M.C., Kumar Manish and Swarup, D. (2009) Oxidative stress and genotoxicity in relation to micro-mineral deficiency in cattle of Bihar districts.Pp 183, Proceedings of the International Summit on “Advancing veterinary Medical care: Challenges and Strategies” and 27th ISVM convention Satellite Seminar on Veterinary Internal Medicine” 19-21 Feb, 2009.

16.  Kumar, Manish; Bhilegaonkar, K.N; Agarwal, R.K. (2008). Prevalence and rapid detection of Salmonella and E.coli in diarrhoeal cases of children and calves and piglets.International symposium on “Food safety, Quality Assurance & Global Trade: Concerns and Strageies”on the occasion of Annual conference of Indian Asssociation of Veterinary Public health

      Specialists, GBPUA&T, Pantnagar, Uttarakhand, India.

 

17.  Kumar, Manish; Bhilegaonkar, K.N; Agarwal, R.K. & Kumar, Pankaj. (2008).RT-PCR for detection of rotavirus from faecal samples of children and animals. Annual conference of Indian Association of veterinary Microbiologists, Immunologists & Specialists in Infectious Diseases and national Symposium on Newer concepts and strategies for Disease Diagnostics & Immunoprophylactics for enhancing Livestock health & production., IVRI, Izatnagar, India.

18.  Kumar, Manish; Bhilegaonkar, K.N; Kumar, Pankaj & Sharma, M.C. (2005). Public health awareness among livestock farmers for sustaining economy. National Seminar on Micro Enterprise Promotion in rural India, Experience, Prospects & Strategies, IVRI, Izatnagar, India.eir Applications” in Veterinary College Khanapara.

   
 
Indian Institute of Technology Guwahati 2013 Department of Biosciences and Bioengineering
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