Department of Biosciences and Bioengineering
Indian Institute of Technology Guwahati

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Department of Biosciences and Bioengineering
Indian Institute of Technology Guwahati
Guwahati 781039

Telephone:
(0361) 258-2250
Fax: (0361) 258-2249
E-mail: biooff@iitg.ernet.in

 

Dr. Ranjan Tamuli, Ph.D.
Associate Professor


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Dr. Ranjan Tamuli
Associate Professor
Department of Biosciences and Bioengineering
Indian Institute of Technology Guwahati
Assam India
PIN 781039

Email: ranjantamuli@iitg.ernet.in
Fax: +91 361 2582249/2690762
Tel: +91 361 2582220


 
Academic

Professional track
 
Associate Professor: Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (25 January 2014– present)
 

Assistant Professor: Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (26 December 2008 – 24 January 2014).

 

Research Interests

Calcium signaling, Genetics, DNA repair
 
Education

PhD: Centre for Cellular and Molecular Biology, 2008.
MSc: Molecular Biology and Biotechnology, Tezpur University, First Class with Distinction, 2002.
BSc: Zoology Major, Dibrugarh University, First Class, 2000.
HS: Science, Dhemaji College, AHSEC, First Division, 1997.
HSLC: Dhemaji Higher Secondary School, SEBA, First Division, 1995.
 
Additional research experiences

           IUSSTF Research Fellow (December 2013 to- December 2014) at the University of California Riverside, USA; Research scholar, 2008 (March to December), research on the regulation of gene expression by estrogen, Department of Environmental and Occupational Health, Florida International University, Miami, USA; and research scholar, 2007 (November)-2008 (March), research on the regulation of gene expression in chromatin, Department of Biochemistry, University of Florida, Gainesville, USA.

Current research

We are interested to understand the molecular mechanism of calcium signaling using Neurospora crassa as a model organism. The calcium ion acts as an intracellular messenger, and calcium signaling is involved in regulating numerous processes biological process in almost all organisms.  We hope to extend our future research to understand the role of calcium in memory, learning, and various other related areas.

Publications

List of Publications in Journals

  1. Deka R., Ghosh A., Tamuli R., and Borkovich KA (2015). Heterotrimeric G Proteins. In H. Drik (ed.), The mycota IV. Springer-Verlag, Berlin, Germany (submitted).

  2. Barman A. and Tamuli R. (2015). Multiple cellular roles of Neurospora crassa plc-1, splA2 and cpe-1 in regulation of cytosolic free calcium, carotenoid accumulation, stress responses, and acquisition of thermotolerance. J. Microbiol. DOI 10.1007/s12275-015-4465-1.

  3. Kumar R. and Tamuli R. (2014). Calcium/calmodulin-dependent kinases are involved in growth, thermotolerance, oxidative stress survival, and fertility in Neurospora crassa. Arch. Microbiol. 196: 295-305.

  4. Deka R. and Tamuli R. (2013). Neurospora crassa ncs-1, mid-1 and nca-2 double mutant phenotypes suggest diverse interaction among three Ca2+ regulating gene products. J. Genetics. 92: 559-563.

  5. Tamuli R., Kumar R., Srivastava D. A. and Deka R. (2013). Calcium signaling. In Neurospora: Genomics and Molecular Biology (ed. D. P. Kasbekar and K.  McCluskey), pp. 35-57. Caister Academic Press, Norfolk, UK.

  6. Deka, R., Kumar, R. and Tamuli, R. (2011). Neurospora crassa homologue of Neuronal Calcium Sensor-1 has a role in growth, calcium stress tolerance, and ultraviolet survival. Genetica 139: 885-894.

  7. Tamuli, R., Kumar R. and Deka, R. (2011). Cellular roles of neuronal calcium sensor-1 and calcium/calmodulin-dependent kinases in fungi. J. Basic Microbio.  51: 120-128.

  8. Goel M, Tamuli R. (2011). RPL10 (ribosomal protein L10). Atlas Genet Cytogenet Oncol Haematol. 15: 425-427.

  9. Mandrawalia R, Tamuli R. (2010). AMOT (angiomotin). Atlas Genet Cytogenet Oncol Haematol. 14:1121-1123.

  10. Deka R, Tamuli R. (2010). CDT1 (chromatin licensing and DNA replication factor 1). Atlas Genet Cytogenet Oncol Haematol.14:812-814.

  11. Singh PK, Tamuli R. (2010). CAPG (capping protein (actin filament), gelsolin-like). Atlas Genet Cytogenet Oncol Haematol. 14:809-811.

  12. Bhattacharyya, M., Tamuli, R. (2010). SEMA3B (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B). Atlas Genet Cytogenet Oncol Haematol. 14:662-664.

  13. Sinha, N., Tamuli, R. (2010). RBBP7 (retinoblastoma binding protein 7). Atlas Genet Cytogenet Oncol Haematol. 14:578-580.

  14. Mandrawalia, R., Tamuli, R. (2010). KCMF1 (potassium channel modulatory factor 1). Atlas Genet Cytogenet Oncol Haematol.14:560-561.

  15. Tamuli, R. (2010). Genome Defense Mechanisms in Neurospora and Associated Specialized Proteins. Journal of Proteins and Proteomics 1: 15-23.

  16. Roy, D., Tamuli, R. (2009). NRF1 (nuclear respiratory factor 1). Atlas Genet Cytogenet Oncol Haematol.13:861-863.

  17. Tamuli, R. and Kasbekar, D. P. (2008). Dominant suppression of repeat-induced point mutation (RIP) in Neurospora crassa by a variant catalytic subunit of DNA polymerase zeta (Pol z). Genetics 178: 1169-1176.

  18. Tamuli, R., Ravindran, C. and Kasbekar, D. P. (2006). Translesion DNA polymerases Pol z, Pol h, Pol i , Pol k and Rev1 are not essential for repeat-induced point mutation (RIP) in Neurospora crassa. J. Biosci. 31: 557-564.

  19. Bhat, A., Tamuli, R., and Kasbekar, D. P. (2004). Genetic transformation of Neurospora tetrasperma, demonstration of repeat-induced point mutation (RIP) in self-crosses and a screen for recessive RIP-defective mutants. Genetics 167: 1155-1164.

Conference presentations:

1. Barman, A., Gohain, D. and Tamuli, R. (2015). Functional analysis of calcium signaling genes and a novel approach to study direct protein-protein interaction in Neurospora crassa. Research Conclave, IIT Guwahati, India, 23rd March.


2. Laxmi V., Kumar A., Tamuli R. (2015). Studies on essential calcium signaling genes calmodulin and calcineurin in Neurospora crassa. Research Conclave, IIT Guwahati, India, 23rd March.


3. Barman, A., Gohain, D., Laxmi, V., Deka, R., Kumar, R. and Tamuli, R. (2015). Cellular functions of calcium signaling machinery in the model filamentous fungus Neurospora crassa’, Molecular intricacies of Plant-pathogenic micro-organisms, Tezpur University, Tezpur, India, 21-22 February.


4.  Laxmi V., Tamuli R. (2015). Expression studies of important calcium signaling genes in Neurospora crassa. IBS-2015, National Symposium on Biophysics and Golden Jubilee Meeting of Indian Biophysical Society, Jamia Millia Islamia, New Delhi 10025, India, February 14-17, 2015.


5. Barman, A., Gohain, D. and Tamuli, R. (2014). Reactive oxygen species and cell signaling in Neurospora crassa’, International conference on disease biology and therapeutics, Institute of Advanced study in Science and Technology, Guwahati, India, 3-5 December.


6. Gohain, D., Barman, A. and Tamuli, R. (2014). Calcineurin and its role in drug resistance in pathogenic fungi, Institute of Advanced study in Science and Technology, Guwahati, India, 3-5 December.


7. Laxmi V., Tamuli R. (2014). Studies of calcium signaling pathway mediated by calmodulin and related proteins in Neurospora crassa. ICDBT‐2014, Internatial Conference on Disease Biology and Therapeutics-2014, Institute of Advanced Study in Science and Techology, Guwahati, India, December 3-5, 2014.


8. Tamuli R. Borkovich, K., (2014). Studies on essential calcium-signaling genes using a conditional promoter-based system. Riverside Postdoctoral Association Symposium, University of California Riverside, USA, 23-24-September.


9. Tamuli R., Deka R., and Borkovich K.A. (2014). A cytogenetic approach to study calcium signaling genes of Neurospora crassa . Neurospora 2014, Asilomar, CA 93950-3704, 6-9 March.


10. Deka R., Kumar R., Laxmi V., Barman A., Vishakha, Gohain D., Borpujari M., Borah R., Singh Kh.S., and Tamuli R.* (2013). Calcium signaling in Neurospora crassa. 8th International Conference on Yeast Biology - Yeast 2013, CSIR-Institute of Microbial Technology (CSIR-IMTECH),Chandigarh 160036, India, 4 - 7 December, 2013.


11. Barman, A. and Tamuli, R. (2013). Role of Ca2+/H+ exchanger and secretory phospholipase A2 in regulating Ca2+ homeostasis in Neurospora crassa, 8th international conference on Yeast biology, Institute of Microbial Technology, Chandigarh, India, 27-30 November.


12. Gohain, D., Deka, R. and Tamuli, R. (2013). Studies on the effect of the post-translational modifications of Neurospora crassa homologue of neuronal calcium sensor-1 in various cell functions, 8th international conference on Yeast biology, Institute of Microbial Technology, Chandigarh, India, 27-30 November.


13. Laxmi V., and Tamuli R. (2013). Function of calmodulin protein in Neurospora crassa. 8th International Conference on Yeast Biology - Yeast 2013, CSIR-IMTECH,Chandigarh 160036, India, 4 - 7 December.


14. Vishakha, and Tamuli R. (2013). Role of Calcium signaling genes in carotenoids accumulation in Neurospora crassa. 8th International Conference on Yeast Biology - Yeast 2013, CSIR-IMTECH,Chandigarh 160036, India, 4 - 7 December.


15. Laxmi, V. and Tamuli, R. (2012). Cellular roles of calmodulin in Neurospora crassa’, 4th Asian chromatin meeting on epigenetic mechanisms in development and disease, Centre for Cellular and Molecular Biology, Hyderabad, India, 22-24 November.


16. Kumar, R. and Tamuli, R. (2012). Involvement of the Neurospora crassa Ca2+/ CaM-dependent protein kinases in full fertility, survival in exposure to heat shock and oxidative stress’, 4th Asian chromatin meeting on epigenetic mechanisms in development and disease, Centre for Cellular and Molecular Biology, Hyderabad, India, 22-24 November.


17. Jagadeesh, K. and Tamuli, R. (2012). Analysis of mitochondrial carrier proteins from Bombyx mori and Neurospora crassa’, International consultative meeting on seribiotechnology (ICMS-2012), Institute of Bioresearches and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal-795001, Manipur, India, 5-7 December.


18. Barman, A. and Tamuli, R. (2012). Comparative analysis of cell signaling pathways and methylation patterns in Bombyx mori and Neurospora crassa’, International consultative meeting on seribiotechnology (ICMS-2012), Institute of Bioresearches and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal-795001, Manipur, India, 5-7 December.


19. Deka, R., Kumar, R., Gedela, R., Sarma, U., Srivastava, D.A., and Tamuli, R. (2011).Calcium signaling in Neurospora crassa. Cell Signaling Networks 2011, Merida, Mexico, 22-27 October.


20. Tamuli, R., Srivastava, D.A., Kumar, R., Deka, R., and Mahor, D. (2011). Genetics of calcium signaling machinery in Neurospora crassa. Comparative genomics of eukaryotic microorganisms: understanding the complexity of diversity, Sant Feliu de Guixols, Spain, 15 - 20 October.


21. Deka, R., Kumar, R., Gedela, R., Tamuli, R., (2011). Investigating cellular functions of the calcium signaling genes in Neurospora crassa. World Congress on Biotechnology-2011, Hyderabad, India, 21-23 March.


22. Deka R, Tamuli R (2011) Cellular roles of the Neurospora crassa neuronal calcium sensor-1 homologue. World Congress on Biotechnology-2011, Hyderabad, India 21-23 March.


23. Kumar R, Tamuli R (2011) Calcium signaling proteins are essential for full fertility in Neurospora crassa. World Congress on Biotechnology-2011, Hyderabad, India 21-23 March.


24. Deka, R., Kumar, R., and Tamuli, R. (2010). Calcium signaling genes in Neurospora crassa. Neurospora 2010 Meeting, Asilomar, USA, 8-11 April.


25. Deka, R., Kumar, R., Mandrawalia, R., and Tamuli, R. (2009). Genetic analysis of calcium signaling genes in Neurospora crassa. International Workshop on “Biology of Yeasts and Filamentous Fungi”, Indo-U.S. Science and Technology Forum, Centre for Cellular and Molecular Biology, Hyderabad, India, 11-14 December.


26. Tamuli, R., Singh, P., Iyer, S., Ramakrishnan, M., Vyas, M. and Kasbekar, D. P. (2007). Two kinds of dominant RIP suppressors in Neurospora crassa. International Symposium on Chromosomes to Genome, Centre for Cellular and Molecular Biology, Hyderabad, India, 3-5 July.


27. Tamuli, R., and Kasbekar, D. P. (2006). Role of repair-related DNA polymerases in RIP. Association for the Promotion of DNA Fingerprinting and other Technologies (ADNAT) Conference, Centre for Cellular and Molecular Biology, Hyderabad, India, 23-24 February.


28. Tamuli, R., and Kasbekar, D. P. (2006). Role of translesion DNA polymerases in RIP. XXIX All India Cell Biology Conference, Industrial Toxicology Research Centre, Lucknow, India, 17-20 January.


29. Tamuli, R., and Kasbekar, D. P. (2005). Analysis of the dominant RIP suppressor of the Adiopodoume strain of Neurospora crassa. International Conference on the Biology of Yeasts, Indian Institute of Science, Bangalore, India, 27-29 September.


30. Tamuli, R., and Kasbekar, D. P. (2005). Genetic and molecular basis of the dominant RIP suppressor of the Adiopodoume strain of Neurospora crassa. XXIII Fungal Genetics Conference, Asilomar, USA, 15-20 March.
 

Research grants:

  1. Molecular investigation of epigenetic modifications caused by environmental pollution using Neurospora crassa as a model system, supported by the Department of Biotechnology (DBT), India, 2013 (ongoing).
  2. Studies on the cellular roles of calcium signaling proteins in Neurospora crassa, supported by the Department of Biotechnology (DBT), India, 2011 (ongoing).
  3. Functional analysis of calcium signaling proteins in Neurospora crassa, supported by the Department of Science and Technology (DST), India, 2010-2013 (completed).
  4. Functional analysis of translasion DNA polymerase Pol eta (h), Pol iota (i), and Pol kappa (k) in Neurospora crassa, IIT Guwahati Start-up grant, 2009-2011 (completed).

Awards and Honours:

        IUSSTF Research Fellow: Awarded Indo-US Research Fellowship 2013 by the Indo-US Science and Technology Forum (IUSSTF) for research (December 9, 2013 to – December 5, 2014) at the University of California Riverside, USA.

Current Lab members:

(1) Ph. D. students:

Sl. No.

Name

Email ID

Period

1.

Vijya Laxmi

vijya@iitg.ernet.in

2011 - present

2.

Ananya Barman

b.ananya@iitg.ernet.in

2011 - present

3.

Dibakar Gohain

g.dibakar@iitg.ernet.in

2013 - present

4.

Ajeet Kumar

ajeetkumar.2014@iitg.ernet.in

2014 - present

(2) M. Tech. Project student:

Sl. No.

Name

Email ID

Period

1.

Manju Nagar

manju.nagar@iitg.ernet.in

2015-16

Lab Alumni:

(1) Ph. D. students:

Sl No.

Name

Year of completion/Degree awarded

1.

Dr. Rekha Deka

2014

2.

Dr. Ravi Kumar

2014

(2) M. Tech. Project students:

Sl No.

Name

Period

1.

Ravi Gadela

2010 - 2011

2.

Dhruv Aditya Srivastava

2011 - 2012

3.

Kumar Jagadeesh

2012 - 2013

4.

Vishakha

2013 - 2014

(3) Others:

      6 JRFs, 7 BTPs, and 14 summer trainees (both internal and external) had undergone research training in the lab during the period from 2009 to 2014.

Teaching experiences (December 2008-present):

B. Tech (UG) Courses:

1.      BT101: Modern Biology

2.      BT 307: Environmental Biotechnology 

3.      BT 208: Molecular Biology and Genetic Engineering 

M. Tech. (PG) Courses:

1.   BT502: Quantitative Biology

2.   BT520: Applied Biology and Bio-engineering Lab

3.   BT503: Genetic Engineering

 
 
Indian Institute of Technology Guwahati 2013 Department of Biosciences and Bioengineering
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