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Selected Publications

MALARIA BIOCHEMISTRY

1. Trivedi, V ., Srivastava, K., Puri, S.K., Maulik, P.R ., Bandyopadhyay, U (2005) Purification and Biochemical Characterization of a Heme Containing Peroxidase from the Human Parasite P. falciparum. Protein  Expr Purif. 37 (2) ; 154-161.

2. Trivedi, V., Chand, P., Maulik, P. R., Bandyopadhyay, U. (2005) Mechanism of Horseradish Peroxidase - Catalyzed Heme Oxidation and Polymerization (β--Hematin formation).Biochem. Biophys. Acta. 1723, 221-228.

3. Trivedi, V., Chand, P., Srivastava, K., Puri, S. K., Maulik, P. R., Bandyopadhyay, U.(2005) Clotrimazole Inhibits Hemo- Peroxidase of P. falciparum and Induces Oxidative Stress : Proposed Antimalarial Mechanism of Clotrimazole.  J. Biol. Chem. 280, 41129-41136.

4. Balaji, SN and Trivedi, V* (2012). Extracellular Methemoglobin mediated early ROS spike triggers osmotic fragility and RBC destruction: An Insight into the enhanced hemolysis during malaria. Ind J Clin Biochem, 27 (2): 178-185 (Publisher : Springer). 

5. Trivedi, V* and Nag, S (2012) In Silico Characterization of Atypical Kinase, PFD0975w from plasmodium kinome: A suitable target for drug discovery. Chem Biol Drug Des. 2012 Apr;79(4):600-9. PMID: 22233458.

6. Nag, S., Prasad, KMN and Trivedi, V* (2012) Identification and screening of antimalarial        Phytochemical reservoir from Northeastern Indian plants to develop PfRIO-2 Kinase  Inhibitor. Eur Food Res Technol, 234: 905-911.

IMMUNOLOGY

1. Stockinger W, Zhang, S.C., Trivedi, V, Jarzylo, L. A., Shieh, E. C., Lane, W.S., Castoreno, A. B. and Nohturfft,A (2006)Differential Requirements for Actin Polymerization, Calmodulin and  Ca²⁺ Define Distinct Stages of Lysosome/Phagosome Targeting. Mol. Biol. Cell, 17 : 1697-1710.

2. Trivedi, V.,Zhang, S.C., Castoreno, A.B.,  Stockinger W, Shieh, E.C., Vyas, J.M., Frickel, E and Nohturfft, A. (2006) Immunoglobin G Signaling Activates Phagosome/Lysosome Targeting. Proc Natl Acad Sci U S A. ;103(48):18226-31.This article was selected as “Science Editor Choice article” ( Science (2006), 314, 5806 : 1661) and featured in ASBMB Today.

3. Trivedi, V, Zhang, SC,  Stockinger, W  and Nohturfft, A (2007). A Cell-Free Scintillation Proximity Assay for Studies on Lysosome-to-Phagosome Targeting. Science STKE,  Vol 2007, Issue 392, pl3.Featured on Faculty of 1000 Biology.

INTRACELLULAR SIGNALING

1. Ahmad, R., Raina, D., Trivedi, V., Ren, J., Rajabi, H., Kharbanda, S., Kufe, D. (2007) MUC1 Oncoprotein activates the IkB kinase β Complex and Constitute NF-κB Signaling. Nature Cell Biology, 9: 1419-1427 (2007). This Article appear as “Featured articles: Cancer Signaling: MUC1 mucks up Apoptosis” in Nature Signaling Updates.

2. Trivedi, V, Adrienne Boire, Boris Tchernychev, Nicole Kaneider, Andrew J Ledger, Katie O’ Callaghan, Lidija Covic & Athan Kuliopulos (2009) Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis By Activating PAR1 At A Novel Cryptic Ligand Site. Cell, 137 (2), 332-43.

3. Swift, S., Xu, J., Trivedi, V., Austin, KM., Tressel, SL., Zhang, L., Covic, L., Kuliopulos, A (2010) A novel PAR1-Interactor, Bicaudal-D1, regulates G protein signaling and internalization. Identification of the microtubule associated protein, Bicaudal-D1, as a novel regulator of PAR1-G Protein Signaling. J. Biol. Chem, Feb, 17, 2010 (Epub ahead of Print).

OTHERS

1. Trivedi, V., Gupta, A., Rao, J.V.K., Saravanan, P., Rao, G.S.J., Rao, A.N., Savithri, H.S. and Subramanya, H.S. (2002) Crystal Structure of Binary and Ternary Complexes of Serine Hydroxymethyl-transferase from B.Stearothermophilus: Insights into the Catalytic Mechanism.J. Biol. Chem. 277, 17161-17169. 

2. Sarkhel, S., Sharon, A., Trivedi, V., Maulik, P. R., Singh, M. M., Venugopalan, P., Ray, S. (2003) Structure-Based Drug Design : Synthesis, Crystal Structure, Biological Evalution and Docking Studies of Mono- and Bis-Benzo[b] Oxepines as Non-steroidal estrogens.Bioorg.Med.Chem.11, 5025-5033.

3. Bhavani S., Trivedi V., Ambili M., Jala V.R., Subramanya H.S., Purnima K., Appaj R.N., Savithri, H.S. (2005) Role of Lys-226 in the Catalytic Mechanism of Bacillus Stearothermophilus Serine Hydroxymethyl-transferase – Crystal Structure  and Kinetic Studies. Biochemistry, 44 (18), 6929 -6937.

4. Prasad, KMN and Trivedi, V* (2012) Engineering High Resolution Horizontal Native  PAGE for Proteins.   International Research Journal of Biotechnology, Vol 3(4) pp 40-46.

* Corresponding Author