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IITG Front gate Malaria Life cycle RBC Aggregation NASI Medal

 

PUBLICATIONS AND PATENT

  1. Trivedi, V., Gupta, A., Rao, J.V.K., Saravanan, P., Rao, G.S.J., Rao, A.N., Savithri, H.S. and Subramanya, H.S. (2002) Crystal Structure of Binary and Ternary Complexes of Serine Hydroxymethyl-transferase from B.Stearothermophilus: Insights into the Catalytic Mechanism.J. Biol. Chem. 277, 17161-17169. [Impact Factor= 4.651] [Publisher: American Society of Biochemistry and Molecular Biology].

  1. Sarkhel, S., Sharon, A., Trivedi, V., Maulik, P. R., Singh, M. M., Venugopalan, P., Ray, S. (2003) Structure-Based Drug Design : Synthesis, Crystal Structure, Biological Evalution and Docking Studies of Mono- and Bis-Benzo[b] Oxepines as Non-steroidal estrogens.Bioorg.Med.Chem.11, 5025-5033. [Impact Factor= 2.338] [Publisher: Elsevier].

  1. Bhavani S., Trivedi V., Ambili M., Jala V.R., Subramanya H.S., Purnima K., Appaj R.N., Savithri, H.S. (2005) Role of Lys-226 in the Catalytic Mechanism of Bacillus Stearothermophilus Serine Hydroxymethyl-transferase – Crystal Structure  and Kinetic Studies. Biochemistry, 44 (18), 6929 -6937. [Impact Factor= 3.377]  [Publisher: American Chemical Society].

  1. Trivedi, V ., Srivastava, K., Puri, S.K., Maulik, P.R ., Bandyopadhyay, U (2005) Purification and Biochemical Characterization of a Heme Containing Peroxidase from the Human Parasite P. falciparum. Protein  Expr Purif. 37 (2) ; 154-161. [Impact Factor= 1.429]  [Publisher: Elsevier].

  1. Trivedi, V., Chand, P., Maulik, P. R., Bandyopadhyay, U. (2005) Mechanism of Horseradish Peroxidase - Catalyzed Heme Oxidation and Polymerization (β--Hematin formation).Biochem. Biophys. Acta. 1723, 221-228. [Impact Factor= 3.848]  [Publisher: Elsevier].

  1. Trivedi, V., Chand, P., Srivastava, K., Puri, S. K., Maulik, P. R., Bandyopadhyay, U.(2005) Clotrimazole Inhibits Hemo- Peroxidase of P. falciparum and Induces Oxidative Stress : Proposed Antimalarial Mechanism of Clotrimazole.  J. Biol. Chem. 280, 41129-41136. [Impact Factor= 4.651] [Publisher: American Society of Biochemistry and Molecular Biology].

  2. Stockinger W, Zhang, S.C., Trivedi, V, Jarzylo, L. A., Shieh, E. C., Lane, W.S., Castoreno, A. B. and Nohturfft,A (2006)Differential Requirements for Actin Polymerization, Calmodulin and  Ca2+ Define Distinct Stages of Lysosome/Phagosome Targeting. Mol. Biol. Cell, 17 : 1697-1710. [Impact Factor= 5.98] [Publisher: American Society for cell biology].

  3. Trivedi, V.,Zhang, S.C., Castoreno, A.B.,  Stockinger W, Shieh, E.C., Vyas, J.M., Frickel, E and Nohturfft, A. (2006) Immunoglobin G Signaling Activates Phagosome/Lysosome Targeting. Proc Natl Acad Sci U S A. ;103(48):18226-31. [Impact Factor= 9.737] [Publisher: Proceeding of the National Academy of Sciences of the United states of America]. This article was selected as “Science Editor Choice article” ( Science (2006), 314, 5806 : 1661) and featured in ASBMB Today.

  4. Trivedi, V, Zhang, SC,  Stockinger, W  and Nohturfft, A (2007). A Cell-Free Scintillation Proximity Assay for Studies on Lysosome-to-Phagosome Targeting. Science STKE,  Vol 2007, Issue 392, pl3.             [Impact Factor= 4.651] [Publisher: Science Press]. Featured on Faculty of 1000 biology.

  5. Ahmad, R., Raina, D., Trivedi, V., Ren, J., Rajabi, H., Kharbanda, S., Kufe, D. (2007) MUC1 Oncoprotein activates the IkB kinase β Complex and Constitute NF-κB Signaling. Nature Cell Biology, 9: 1419-1427 (2007). [Impact Factor= 20.76] [Publisher: Nature Publishing group]. This Article appear as “Featured articles: Cancer Signaling: MUC1 mucks up Apoptosis” in Nature Signaling Updates. 

  6. Trivedi, V, Adrienne Boire, Boris Tchernychev, Nicole Kaneider, Andrew J Ledger, Katie O’ Callaghan, Lidija Covic & Athan Kuliopulos (2009) Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis By Activating PAR1 At A Novel Cryptic Ligand Site. Cell, 137 (2), 332-43. [Impact Factor= 31.95] [Publisher: Cell Press].

  1. Swift, S., Xu, J., Trivedi, V., Austin, KM., Tressel, SL., Zhang, L., Covic, L., Kuliopulos, A (2010) A novel PAR1-Interactor, Bicaudal-D1, regulates G protein signaling and internalization. Identification of the microtubule associated protein, Bicaudal-D1, as a novel regulator of PAR1-G Protein Signaling. J. Biol. Chem, Feb, 17, 2010 (Epub ahead of Print). [Impact Factor= 4.651] [Publisher: American Society of Biochemistry and Molecular Biology].

  2. Balaji, SN and Trivedi, V* (2012). Extracellular Methemoglobin mediated early ROS spike triggers osmotic fragility and RBC destruction: An Insight into the enhanced hemolysis during malaria. Ind J Clin Biochem, 27 (2): 178-185 [Corresponding Author]. [Publisher: Springer].  

  1. Trivedi, V* and Nag, S (2012) In Silico Characterization of Atypical Kinase, PFD0975w from plasmodium kinome: A suitable target for drug discovery. Chem Biol Drug Des. 2012 Apr;79(4):600-9. [Corresponding Author] [Impact Factor= 2.46]. [Publisher: Wiley Press].

  2. Prasad, KMN and Trivedi, V* (2012) Engineering High Resolution Horizontal Native PAGE for Proteins. International Research Journal of Biotechnology, Vol 3(4) pp 40-46. [Corresponding Author]

  1.  Nag, S., Prasad, KMN and Trivedi, V* (2012) Identification and screening of antimalarial Phytochemical reservoir from northeastern Indian plants to develop PfRIO-2 Kinase Inhibitor. Eur Food Res Technol, 234: 905-911. [Corresponding Author]. [Impact Factor= 1.43] [Publisher: Springer].

  2. Nag, S., Prasad, KMN., Bhowmick, A., Deshmukh, R., Trivedi, V* (2013) PfRIO-2 Kinase is a potential therapeutic target of antimalarial protein kinase inhibitors. Curr Drug Discov Technol, 10, 85-91. [Corresponding Author]. [Cites Per Doc= 3.0] [Publisher: Bentham Science Publisher].

  1. Deshmukh, R., Trivedi, V* (2013)  Methemoglobin exposure produces toxicological effects in macrophages due to multiple ROS spike induced apoptosis. Toxicology in    Vitro, 27: 16-23. [Corresponding Author] [Impact Factor= 2.650] [Publisher: Elsevier].

  2. Dwivedi, A., Prasad, KMN., Trivedi, V., Iyer, P (2012) Interaction of Heme Proteins with Anionic Polyfluorene: In-sights into Physiological Effects, Folding Events and Inhibition Activity. Appl. Mater. Interfaces, 4 (11), 6371–6377. [Impact Factor= 5.008] [Publisher: American Chemical Society Publications].

  1. Balaji, SN and Trivedi, V* (2013) Extracellular Methemoglobin Primes Red Blood Cell Aggregation in Malaria: An In-Vitro Mechanistic Study. FEBS Letters, 587, 350-357. [Corresponding Author] [Impact Factor= 3.58] [Publisher: Elsevier]

  2. Balaji, SN and Trivedi, V* (2013) Methemoglobin incites the primaquine toxicity through single electron oxidation and modification. J Basic Clin Physiol Pharmacol; 24(2): 105–114. [Corresponding Author] [Publisher: De Gruyter].

  1. Balaji, SN and Trivedi, V* (2013) Mechanism based suicidal inactivation of      methemoglobin protects oxidative stress induced RBC lysis: Role of thiyl radicals of NAC in antioxidant potentials. Current Molecular Medicine, 13 (6), 1000-1009. [Corresponding Author] [Impact Factor= 4.6] [Publisher: Bentham Science Publisher].

  2. Deshmukh, R and Trivedi, V* (2013) Pro-stimulatory role of methemoglobin in inflammation through Hemin Oxidation and Polymerization. Inflamm Allergy Drug Targets, 12 (1), 68-78. [Corresponding Author] [Cites Per Doc= 2.6] [Publisher: Bentham Science Publisher].

  1. Nag, S., Chouhan, DK., Balaji, SN., Chakraborty, A., Lhouvum, K., Bal, C., Sharon, A and Trivedi, V* (2013) Comprehensive screening of heterocyclic compound libraries to identify novel inhibitors for PfRIO-2 kinase through docking and substrate competition studies. Med Chem Res, 22; 4737-4744. [Corresponding Author] [Impact Factor= 1.6] [Publisher: Springer].

  2. Lhouvum, K., Ramakrishnan, V and Trivedi, V* (2013) Insight into structural and Biochemical determinants of substrate specificity of PFI1625c: Correlation analysis of protein-peptide molecular models. J of molecular graphics and modeling, 43, 21-30. [Corresponding Author] [Impact Factor= 2.3] [Publisher: Elsevier]

  1. Manu S, Rohitas Deshmukh, KMN Prasad and Trivedi, V* (2013) Screening and Characterization of Antimalarial Heme Polymerase Inhibitors From Dietary Garlic Cloves. European journal of medicinal plants, 3(3) 474-484. [Corresponding Author]. [Publisher: Science Domain International].

  2. Jain, A., Trivedi, V* (2013) Docking and Virtual screening to identify PKC agonists: potentials in anticancer therapeutics. Current Computer-Aided Drug Design (In Press). [Corresponding Author]. [Impact Factor= 1.54] [Publisher: Bentham Science Publisher].

  1. Afsana Parween, Arnish Chakraborty, Ananda Kumar Konreddy, Harapriya Chakravarty, Ashoke Sharon, Vishal Trivedi*, Chandralata Bal* (2013) Skeletal hybridization and PfRIO-2 kinase modeling for synthesis of α-pyrone analogs as anti-malarial agent. European Journal of Medicinal Chemistry, 70, 607-612. [Corresponding Author]. [Impact Factor= 3.5] [Publisher: Elsevier]

  1. Kuldeep, Niranjan Kumar V, Trivedi,V., Chhitar M Gupta, and Amogh Anant Sahasrabuddhe (2014) A novel actin-related protein in Leishmania regulates both the mitochondrial activity and flagellar assembly. Mol Microbiol. Dec 4. [Epub ahead of print] [Impact Factor= 4.96] [Publisher: Wiley]  [COVER PAGE ARTICLE].

  2.  B. Muthuraj, Rohitas Deshmukh, Vishal Trivedi*, Parameswar K. Iyer* (2014) Fluorescein-based Rapid and Highly Selective “turn-on and turn-off” sensor for copper and nitric oxide generated in-vivo. Appl. Mater. Interfaces, (in press) [Co-Corresponding Author] [Impact Factor= 5.008] [Publisher: American Chemical Society Publications].

  1. Lhouvum, K., Kshitij, B and Trivedi, V* (2014) Molecular modeling and correlation of PFI1625-peptide models of bio active peptides with antimalarial properties Med Chem Res, in press [Impact Factor= 1.6] [Publisher: Springer] [Corresponding Author].

  2. Deshmukh, R and Trivedi, V* (2014) Methemoglobin Mediated Immuno-Toxicity Modulation Of Pro-Oxidant Molecules Towards Macrophage During Malaria. PLoS One. 2014 Jul 31;9(7):e103706.[Corresponding Author].

  1. Deshmukh, R* and Trivedi, V* (2014) Role of Pro-Oxidants from Infected RBCS in Disturbing Homeostasis and Pathogenesis During Malaria. Austin J Biotechnol Bioeng - Volume 1 Issue 7. [Co-Corresponding Author]

  2. A. Mehra, Gaurav Jerath, Ramakrishnan, V and Trivedi, V* (2015) Characterization of ICAM-1 Biophore to design cyto-adherence blocking peptides. J of molecular graphics and modeling, 57C:27-35. [Corresponding Author]. [Impact Factor= 2.3] [Publisher: Elsevier].

  1.  Balaji, SN., Jawed, AM*., Singh, SJ and Trivedi, V (2015) Synthesis and antimalarial potentials of curcumin analogues containing heterocyclic rings. [Accepted for publication in Arabian Journal of chemistry]. [Impact Factor= 2.3] [Publisher: Elsevier]

  2. Malik, AH., Hussain, S., Tanwar, AS., Layek, S., Balaji, SN., Vishal Trivedi*., Iyer, PK (2015) Anionic conjugated polymer as a multi-action sensor for the sensitive detection of Cu2+, PPi, real-time ALP assaying and cell imaging. Analyst (In Press) [Co-Corresponding Author].

  3. Muthuraj, B., Layek, S., Balaji, SN., Trivedi, V*., Iyer, PK*. Multiple Function Fluorescein Probe Performs Metal Chelation, Disaggregation and Modulation of Aggregated Aβ and Aβ-Cu Complex. ACS Chemical Neuroscience [Accepted] [Co-Corresponding Author]

     

Patent

Antimicrobial Peptides. 

Inventors: Vibin Ramakrishnan, Prakash Kishore Hazam, Nitin Chaudhary, Vishal Trivedi and Gaurav Jerath. Patent No. 333/KOL/2015. Dated 26.03.2015