Indian Institute of Technology Guwahati
Department of Biosciences and Bioengineering

Stem Cell and Cancer Biology Group

You are here: IITG> BT>People> Faculty> Dr. Bithiah Grace Jaganathan>Research


We are studying the role of bone marrow stroma in the development and progression of hematologic malignancies and other cancers. Recent evidences show that the bone marrow stroma through direct cell-cell contact and/or  secreted factors contribute to cancer development, progression and chemo-resistance.

Cell Therapy
It has been known that adult-marrow-derived mesenchymal stem cells (MSC) has tremendous potential to differentiate into bone, cartilage, muscle, marrow stroma, tendon-ligament, fat and other connective tissues. The use of stem cells has been limited due to requirement of large number of cells for therapy as most of these cells disappear shortly after transplantation. Therefore we are trying to understand their in vivo survival/death mechanisms that might help to improve the efficacy of these cells for therapy.

 Stem Cells
Our lab is interested in studying Mesenchymal Stem Cells (MSC), which are adult multipotent cells from bone marrow and other connective tissue.  MSC have got the capacity to differentiate into mesenchymal tissue cells such as adipocytes, osteocytes, chondrocytes and muscle cells. Our special focus is on the biology, differentiation potential, aging, cytoskeleton and migration of MSC.

Research Projects

1. Study of apoptotic pathways (DBT-NE twinning project)
2. Role of Rho GTPase RHOA (DBT RGYI project)
3. Cytoskeleton and migration (DST Fast Track Project)
4. Bone marrow microenvironment (ICMR-Adhoc project)

5. Isolation of stem cells from limbal and extra ocular muscle (ICMR seed grant)


1. Hematology, Gauhati Medical College Hospital, Guwahati, India
2. Sri Sankaradev Nethralaya, Guwahati, India
3. University of Baroda, India

Last updated: Mar 2015