Indian Institute of Technology Guwahati
Department of Biotechnology

Stem Cell and Cancer Biology Group
 

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Research

Stem Cells

Our lab is interested in studying Mesenchymal Stem Cells (MSC), which are adult multipotent cells from bone marrow and other connective tissue.  MSC have got the capacity to differentiate into mesenchymal tissue cells such as adipocytes, osteocytes, chondrocytes and muscle cells. Our special focus is on the biology, differentiation potential, aging, cytoskeleton and migration of MSC.

Cancer
We are studying the role of bone marrow stroma in the development and progression of hematologic malignancies and other cancers. Recent evidences show that the bone marrow stroma through direct cell-cell contact and/or  secreted factors contribute to cancer development, progression and chemo-resistance.

 Cell Therapy
It has been known that adult-marrow-derived mesenchymal stem cells (MSC) has tremendous potential to differentiate into bone, cartilage, muscle, marrow stroma, tendon-ligament, fat and other connective tissues. The use of stem cells has been limited due to requirement of large number of cells for therapy as most of these cells disappear shortly after transplantation. Therefore we are trying to understand their in vivo survival/death mechanisms that might help to improve the efficacy of these cells for therapy.

Research Projects

Funded by
1.  DBT, Govt. of India
2. ICMR, Govt. of India

3.  DST, Govt. of India

Collaborators

1. University of Baroda, India
2. Sri Sankaradev Nethralaya, Guwahati, India
3. Gauhati Medical College Hospital, Guwahati, India

 
Last updated: August 2012