Indian Institute of Technology Guwahati
Department of Biosciences and Bioengineering

Stem Cell and Cancer Biology Group
 

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Research

What we do?

Why we do?

How we do?

Where we do?

What we do?

Through collaborations with hospitals in the North East, we study the therapeutic use of stem cells  in tissue repair and regeneration.

We also study chemo-resistance in several cancers with special focus on bone metastasis.

Why we do?

Tissue damage occurs during aging, injury or infection. The regenerative and repair potential of tissues and organs in the human body are varied and limited and there is a great need for therapeutic approaches that result in efficient tissue repair and regeneration. Stem cells are a great source of cells for such applications and they can be modified genetically or tweaked by application of small molecules or extra cellular matrix substances.


The life of cancer patients have been extended by many therapeutic molecules and methods developed in the recent past. However, cancer chemo-resistance is also a growing problem and a cause for great concern in securing the lives of cancer patients. Our group focuses on the mechanisms of cancer chemo-resistance - oncogene dependent/independent pathways and most importantly the microenvironment mediated chemo-resistance.

How we do?

Stem cell characterization is done through ex vivo culture and by employing several fluorescent techniques.

Cancer target molecule identification is done by ex vivo methods and validation of our results are performed using primary cancer tissue samples

Where we do?

Our lab is well-equipped for the research work we desire to pursue and facilities are constantly added to increase the scope of the work we do.

Research Projects

  1. Study of apoptotic pathways (DBT-NE twinning project)
  2. Role of Rho GTPase RHOA (DBT RGYI project)
  3. Cytoskeleton and migration (DST Fast Track Project)
  4. Bone marrow microenvironment (ICMR-Adhoc project)
  5. Isolation of stem cells from limbal and extra ocular muscle (ICMR seed grant)
  6. Pilot project grant on "Cancer Research"

Collaborators

1. Hematology, Gauhati Medical College Hospital, Guwahati, India
2. Sri Sankaradeva Nethralaya Hospital, Guwahati, India
3. University of Baroda, India

 
Last updated: Mar 2016